2. Signaling Pathways
  3. Immunology/Inflammation
  4. Interleukin Related

Interleukin Related

IL

Interleukin Related

Related Products

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Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

Interleukin Related Isoform Specific Products:

Interleukin Related Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N3380
    Linderaspirone A
    		Inhibitor
    Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .
    Linderaspirone A
  • HY-172402
    Vasoactive intestinal peptide
    		Modulator
    Vasoactive intestinal peptide is an agonist of VPAC1/VPAC2 receptor (G-protein-coupled receptors). Vasoactive intestinal peptide reduces corneal perforation rate, bacterial load, and excessive neutrophil infiltration in Pseudomonas aeruginosa-induced keratitis models. Vasoactive intestinal peptide enhances anti-inflammatory mediators like IL-10 and TGF-β, inhibites pro-inflammatory factors such as IL-1β and TNF-α, and upregulates lipid mediator-related enzymes (SOCS3, COX-2, ALOX12) to promote inflammation resolution. Vasoactive intestinal peptide is promising for research of ocular infectious diseases.
    Vasoactive intestinal peptide
  • HY-P991489
    ENx-108A
    		Inhibitor
    ENx-108A is a human IgG4 monoclonal antibody (mAb) targeting IL-11. BI-765423 can be used in fibrotic diseases research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003).
    ENx-108A
  • HY-P99728
    Melredableukin alfa
    Melredableukin alfa (RO-7049665) is a fusion protein that consists of a human IgG1-κ fused to a mutated human interleukin 2 (IL2 mutein) via a peptide linker. Melredableukin alfa can be used for the research of autoimmune hepatitis and ulcerative colitis.
    Melredableukin alfa
  • HY-W768336
    Gluconate-13C6 sodium
    Gluconate sodium-13C6 (D-Gluconic acid sodium salt-13C6) is the 13C-labeled Gluconate sodium (HY-B1092A). Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury.
    Gluconate-<sup>13</sup>C<sub>6</sub> sodium
  • HY-P990058
    Varokibart
    		Inhibitor
    Varokibart (TEV-53275) is a human IgG4λ antibody targeting IL5.
    Varokibart
  • HY-161396
    Anti-inflammatory agent 76
    		Inhibitor
    Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, IL-1β and IL-6 inhibitory activities.
    Anti-inflammatory agent 76
  • HY-N1178R
    Taraxasterol (Standard)
    Taraxasterol (Standard) is the analytical standard of Taraxasterol. This product is intended for research and analytical applications. Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases.
    Taraxasterol (Standard)
  • HY-169731
    RO27-3225 trifluoroacetate
    		Inhibitor
    RO27-3225 trifluoroacetate is a peptide agonist of melanocortin receptor 4 (MC4R) with neuroprotective and anti-inflammatory activity with an EC50 value of 1 nM, while 8 nM for MC1R. RO27-3225 trifluoroacetate reverses hemorrhagic shock, reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal IL-1β and TNF-α levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation.
    RO27-3225 trifluoroacetate
  • HY-157147
    NLRP3-IN-24
    NLRP3-IN-24 (Compounds 15a) is an inhibitor against NLRP3. NLRP3-IN-24 has an inhibitory effect on the activation of NLRP3 inflammasome.
    NLRP3-IN-24
  • HY-P990836
    Anti-IL-9 Antibody (MH9A4)
    		Inhibitor
    Anti-IL-9 Antibody (MH9A4) is a kind of mouse IgG2b, κ chimeric antibody, targeting to human IL-9. The recommend isotype control of Anti-IL-9 Antibody (MH9A4): Mouse IgG2b kappa, Isotype Control (HY-P99982).
    Anti-IL-9 Antibody (MH9A4)
  • HY-P5837
    Citrullinated LL-37 2cit
    		Inhibitor
    Citrullinated LL-37 2cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 2cit reduces LL-37 activity against HRV at 10 μg/mL and reduces the antibacterial effect of LL-37. Citrullinated LL-37 2cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B. Citrullinated LL-37 2cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion.
    Citrullinated LL-37 2cit
  • HY-N8309R
    Luteolin-4'-O-glucoside (Standard)
    		Inhibitor
    Luteolin-4'-O-glucoside (Standard) is the analytical standard of Luteolin-4'-O-glucoside. This product is intended for research and analytical applications. Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC50 of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity.
    Luteolin-4'-O-glucoside (Standard)
  • HY-RS06776
    Il6 Rat Pre-designed siRNA Set A
    		Inhibitor

    Il6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Il6 Rat Pre-designed siRNA Set A
    Il6 Rat Pre-designed siRNA Set A
  • HY-P990796
    Anti-Mouse IL-2 Antibody (S4B6-1)
    		Inhibitor
    Anti-Mouse IL-2 Antibody (S4B6-1) is a kind of rat IgG2a kappa in vivo mouse antibody, targeting to IL-2. The recommend isotype control of Anti-Mouse IL-2 Antibody (S4B6-1): Rat IgG2a kappa, Isotype Control (HY-P990679).
    Anti-Mouse IL-2 Antibody (S4B6-1)
  • HY-P991471
    GB-0895
    		Inhibitor
    GB-0895 is a human monoclonal antibody (mAb) targeting TSLP. GB-0895 can be used in Asthma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    GB-0895
  • HY-P99846
    Dectrekumab
    Dectrekumab (QAX576) is a human monoclonal antibody that targets IL-13. Dectrekumab significantly improves intraepithelial esophageal eosinophil counts and dysregulated esophageal disease-related transcripts with Eosinophilic esophagitis (EoE) in a sustained manner and can be used for inflammation and immunology related research.
    Dectrekumab
  • HY-131194
    JAK2/STAT3-IN-1
    		Inhibitor
    JAK2/STAT3-IN-1 (compound (S)-10a) is a potent GP130 inhibitor with an IC50 of 3.04 µM. JAK2/STAT3-IN-1 shows anti-tumor activity.
    JAK2/STAT3-IN-1
  • HY-RS06775
    Il6 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Il6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Il6 Mouse Pre-designed siRNA Set A
    Il6 Mouse Pre-designed siRNA Set A
  • HY-173404
    VB-85247
    		Inducer
    VB-85247 is a STING agonist. VB-85247 induces upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as maturation and activation of dendritic cells by activating the STING pathway. VB-85247 can achieve regression of intrabladder tumors and can be used in bladder cancer research.
    VB-85247
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Interleukin Related Isoform Comparison

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